In the rapidly evolving field of medicine and dentistry, a new concern has emerged that is causing a stir in professional circles and social media platforms alike. Referred to as “Ozempic Teeth,” This term is gaining traction as it is associated with a range of dental issues that patients are reporting, potentially linked to GLP-1 receptor agonists such as Ozempic®, Wegovy®, and Mounjaro®.
Originally developed to treat type 2 diabetes, these medications have recently gained widespread popularity as weight loss tools. However, as more patients incorporate GLP-1s into their health routines, dental professionals notice an uptick in unexpected oral health complications.
What Are GLP-1 Receptor Agonists?
GLP-1 (glucagon-like peptide-1) receptor agonists are injectable drugs designed to lower blood sugar, improve insulin sensitivity, and suppress appetite. The most commonly prescribed brands—Ozempic® (semaglutide), Wegovy® (semaglutide for weight loss), and Mounjaro® (tripeptide)—have been associated with dramatic weight loss results.
However, they also come with side effects such as:
- Nausea
- Vomiting
- Appetite suppression
- Gastrointestinal discomfort
And now, potentially, oral health changes.
What Is “Ozempic Teeth”?
The term “Ozempic Teeth” is not a formal medical diagnosis but rather a patient-coined phrase referring to:
- Tooth cracking or chipping
- Dry mouth (xerostomia)
- Enamel erosion
- Gum sensitivity
- Increased dental pain
Many dental providers, including Dr. Marielaina Perrone, DDS, are seeing more patients with these symptoms who are also taking GLP-1 medications.
“We’re hearing from patients who say their teeth feel brittle or are cracking more easily,” says Dr. Perrone. “In some cases, they’ve had no prior history of decay or dental issues.”
There is no current clinical study directly linking GLP-1 drugs to tooth damage. However, several plausible explanations are emerging based on clinical observation and known side effects:
1. Chronic Dry Mouth (Xerostomia)
A common side effect of GLP-1 medications is nausea and reduced appetite, which can lead to reduced hydration and salivary flow.
“Saliva protects our teeth from acid attacks, supports enamel remineralization, and controls harmful bacteria,” Dr. Perrone explains. “Without it, the mouth becomes far more vulnerable to decay, erosion, and infections.”
2. Nutritional Deficiencies
Rapid weight loss or appetite suppression can lead to inadequate calcium, vitamin D, and other essential nutrients necessary for maintaining bone and tooth integrity.
3. Gastroesophageal Reflux
Some patients report reflux-like symptoms with GLP-1 usage, which could expose the oral cavity to stomach acids and contribute to enamel erosion.
4. Teeth Grinding (Bruxism)
While not a reported side effect of GLP-1s, some clinicians suggest that systemic stress and metabolic shifts could trigger or exacerbate nocturnal bruxism in some individuals.
A Closer Look: Clinical Observations in Henderson, NV
At her practice in Green Valley, Henderson, Marielaina Perrone, DDS has taken a proactive approach when treating patients who disclose GLP-1 medication use. This proactive stance should reassure you, as a dental professional, that you are well-equipped to handle these emerging issues.
“When a patient tells us they’re on Ozempic or Wegovy, we immediately ask about dry mouth, hydration levels, and any recent changes in their bite or tooth sensitivity,” Dr. Perrone says. “We’ve even added questions about these medications to our intake forms.”
Patient Case Snapshot
One 56-year-old female patient reported two cracked molars within six months of starting semaglutide. She had no history of decay, bruxism, or dental trauma.
“She told me she felt like her teeth were becoming more fragile,” recalls Dr. Perrone. “We reviewed her nutrition and hydration habits and developed a care plan focused on saliva support and enamel protection.”
Her treatment included:
- Prescription fluoride toothpaste
- Xylitol mouth rinses
- Nightguard therapy
- Dietary counseling
What Can Dental Professionals Do?
While research is still emerging, dental teams can take action now by:
-Asking patients about GLP-1 medication use during medical history updates
-Monitoring for signs of xerostomia, erosion, and tooth fractures
-Recommending fluoride treatments, saliva substitutes, and hydration strategies
-Coordinating with the patient’s primary care provider or endocrinologist when necessary
-Educating patients on the oral-systemic connection and potential risks
“Communication is key,” Dr. Perrone emphasizes. “We’re not suggesting patients stop these medications but encourage a more collaborative, preventive approach.”
Final Thoughts
The rise of GLP-1 medications marks a powerful shift in weight management and diabetes care. But like any medical advancement, new side effects can surface—and it’s up to interdisciplinary teams to investigate and respond.
Understanding the potential link between GLP-1 drugs and oral health is crucial for dental professionals. This knowledge can help them better protect their patients and respond with evidence-informed strategies. It also underscores the need for further research in this area.
“We’re still learning,” says Dr. Perrone. “But the best dentistry is proactive. If we spot early signs of trouble, we can help patients avoid long-term damage—without compromising their overall health goals.”
About the Author
Dr. Marielaina Perrone, DDS, is a highly experienced general and cosmetic dentist in Henderson, NV. She is dedicated to helping patients achieve optimal oral and systemic health through preventive care, smile restoration, and compassionate education. Her clinical interests include dental implants, TMJ therapy, and the intersection of medicine and oral health.